Anti-proliferative effects of paroxetine alone or in combination with sorafenib in HepG2 cells

Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells.

We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's anticancer activity on human hepatoma HepG2 cells in vitro and in vivo, and to eluc...

Preferential T cell Expansion by Artificial Antigen Presenting Cells Expressing 4-1BBL Alone or in Combination with CD80 or CD86

Comparison of the Effects of Myo-Inosito Alone or in Combination with Mem Vitamins on Embryo Development in Sanjabi Sheep

Purpose: The objective of this study was to evaluate the effects of myo-inositol alone or in combination with MEM vitamins on embryo development in sanjabi sheep.Materials and Methods: Sheep Cumulus Oocytes Complexes (COCs) were matured in vitro at 39ºC, in humidified 5% CO2 atmosphere for 22-24 h. There were three treatments, culture in synthetic oviductal fluid medium (treatment I), culture i...

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells

Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Celecoxib (Celebrex®) is a selective cyclooxygenase-2 (COX-2) inhibitor which exhibits antitumor eff...

Modulating effects of melatonin, vitamin C and saffron alone or in combination on radiation induced cell lethality; an in vitro study with Hela cells

Introduction: Radiation countermeasures are defined as use of an agent to minimize the deleterious effects of radiation therapy by administering the compound after the radiation exposure has occurred, regardless of toxicity. In spite of extensive study in this field, yet there is no suitable radioprotector introduced. In this study two naturally occurring antioxidants were stu...